Jaak Panksepp, a radical in the field of neuroscience, thinks that depression is caused by one of his seven theorized “primary-process affective systems,” SEEKING, shutting down. The SEEKING system is described as what creates the drive to explore our environment and seek information. In cases of depression, he theorizes that this system shuts down because of the activation of the PANNIC-GRIEF system, caused by perceptions of isolation and loss. Panksepp is developing a treatment for depression that works by stimulating the region of the brain associated with the SEEKING system.
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