Fibro Daily

Fluoxetine Leads to New Neurons in the Adult Normal Cortex

Fibro Daily January 10, 2013

The antidepressant fluoxetine’s ability to generate the production of new neurons in the adult normal cortex is the focus of an online study that appears in Neuropsychopharmacology.

A research team from The Institute for Comprehensive Medical Science, Fujita Health University, Aichi, performed the study which is the first one to show this result.

Fluoxetine is one of the most commonly used anti-depressants on the market. From Medical News Today:

Tsuyoshi Miyakawa, Koji Ohira, and their colleagues employed fluoxetine, a selective serotonin reuptake inhibitor, and one of the most widely used antidepressants, to stimulate the production of new neurons from L1-INP cells. A large percentage of these newly generated neurons were inhibitory GABAergic interneurons, and their generation coincided with a reduction in apoptotic cell death following ischemia. This finding highlights the potential neuroprotective response induced by this antidepressant drug. It also lends further support to the postulation that induction of adult neurogenesis in cortex is a relevant prevention/treatment option for neurodegenerative diseases and psychiatric disorders.

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