Research on patients with Chronic Fatigue Syndrome has suggested that they perform just as well during exercise as controls, leading some to suggest that patient’s complains of exercise intolerance are ill-founded. However, a recent study had participants engage in a second test the following day. In this test, participants with inME/CFS performed significantly worse than healthy controls. Based on performance results alone, the difference was sufficient enough to predict whether a participant did or did not have ME/CFS with 95 percent accuracy. This suggests the presence of post-exertional fatigue, or a period of intense exhaustion after exercise.
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